TITANIUM DIOXIDE

1. Product Identification

Synonyms: Titanium (IV) Oxide; C.I. 77891; Titania
CAS No.: 13463-67-7
Molecular Weight: 79.87
Chemical Formula: TiO2
Product Codes:
J.T. Baker: 4162, 4962
Mallinckrodt: 0993
GRADE     Rutile

2. Composition/Information on Ingredients

Ingredient
CAS No
Percent
Hazardous
---------------------------------------
------------
------------
---------
Titanium Dioxide
13463-67-7
99 - 100%
Yes

3. Hazards Identification

Emergency Overview
--------------------------
WARNING! MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT. MAY AFFECT LUNGS. SUSPECT CANCER HAZARD. CONTAINS TITANIUM DIOXIDE WHICH MAY CAUSE CANCER. Risk of cancer depends on level and duration of exposure.

SAF-T-DATA^(tm) Ratings (Provided here for your convenience)
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Health Rating: 2 - Moderate (Cancer)
Flammability Rating: 0 - None
Reactivity Rating: 1 - Slight
Contact Rating: 1 - Slight
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: Green (General Storage)
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Potential Health Effects
----------------------------------

Inhalation:
May cause mild irritation to the respiratory tract.
Ingestion:
Not expected to be a health hazard via ingestion.
Skin Contact:
May cause mild irritation and redness.
Eye Contact:
May cause mild irritation, possible reddening.
Chronic Exposure:
Titanium Dioxide may cause cancer in humans. Long-term exposure to titanium dioxide dust may result in mild fibrosis (scarring of the lungs).
Aggravation of Pre-existing Conditions:
Persons with pre-existing lung disease may be more susceptible to the effects of this substance.

4. First Aid Measures

Inhalation:
Remove to fresh air. Get medical attention for any breathing difficulty.
Ingestion:
Not expected to require first aid measures. If large amounts were swallowed, give water to drink and get medical advice.
Skin Contact:
Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention if irritation develops.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention if irritation persists.

5. Fire Fighting Measures

Fire:
Not considered to be a fire hazard.
Explosion:
Not considered to be an explosion hazard.
Fire Extinguishing Media:
Use any means suitable for extinguishing surrounding fire.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.

6. Accidental Release Measures

Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Sweep up and containerize for reclamation or disposal. Vacuuming or wet sweeping may be used to avoid dust dispersal.

7. Handling and Storage

Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
Titanium Dioxide:
- OSHA Permissible Exposure Limit (PEL) -
15 mg/m3 (TWA).
- ACGIH Threshold Limit Value (TLV) -
10 mg/m3 (TWA), A4 - Not classifiable as a human carcinogen.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a half-face dust/mist respirator may be worn for up to ten times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. A full-face piece dust/mist respirator may be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate regulatory agency, or respirator supplier, whichever is lowest. For emergencies or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.

9. Physical and Chemical Properties

Appearance:
White Powder.
Odor:
Odorless.
Solubility:
Insoluble in water.
Specific Gravity:
4.26
pH:
ca. 6 - 7
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
2500 - 3000C (4532 - 5432F)
Melting Point:
1855C (3371F)
Vapor Density (Air=1):
Not applicable.
Vapor Pressure (mm Hg):
Not applicable.
Evaporation Rate (BuAc=1):
No information found.

10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
No information found.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
For Titanium Dioxide: A violent reaction with lithium occurs around 200C (392F) with a flash of light; the temperature can reach 900C. Violent or incandescent reaction may also occur with other metals such as aluminum, calcium, magnesium, potassium, sodium, and zinc.
Conditions to Avoid:
Dusting and incompatibles.

11. Toxicological Information

Toxicological Data:
No LD50/LC50 information found relating to normal routes of occupational exposure. Investigated as a tumorigen and mutagen.
Carcinogenicity:
IARC classification: Group 2B - Possibly carcinogenic to humans.


NIOSH considers this substance to be a potential occupational carcinogen.

--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient
Known
Anticipated
IARC Category
------------------------------------
-----
-----------
-------------
Titanium Dioxide (13463-67-7)
No
No
2B 

12. Ecological Information

Environmental Fate:
No information found.
Environmental Toxicity:
No information found.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

Not regulated.

15. Regulatory Information

--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient
TSCA
EC
Japan
Australia
-----------------------------------------------
----
---
-----
---------
Titanium Dioxide (13463-67-7)
Yes
Yes
Yes
Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient
Korea
DSL
NDSL
Phil.
-----------------------------------------------
-----
---
----
-----
Titanium Dioxide (13463-67-7)
Yes
Yes
No
No
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302-
------SARA 313------
Ingredient
RQ
TPQ
List
Chemical Catg.
-----------------------------------------
---
-----
----
--------------
Titanium Dioxide (13463-67-7)
No
No
No
No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA-
-TSCA-
Ingredient
CERCLA
261.33
8(d)
-----------------------------------------
------
------
------
Titanium Dioxide (13463-67-7)
No
No
No
Chemical Weapons Convention:
No
TSCA 12(b):
No
CDTA:
No SARA 311/312:
Acute: Yes
Chronic: Yes
Fire: No
Pressure: No Reactivity: No
(Pure / Solid)

Australian Hazchem Code: None allocated.
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.

16. Other Information

NFPA Ratings: Health: 1 Flammability: 0 Reactivity: 0
Label Hazard Warning:
WARNING! MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT. MAY AFFECT LUNGS. SUSPECT CANCER HAZARD. CONTAINS TITANIUM DIOXIDE WHICH MAY CAUSE CANCER. Risk of cancer depends on level and duration of exposure.
Label Precautions:
Avoid contact with eyes, skin and clothing.
Wash thoroughly after handling.
Avoid breathing dust.
Keep container closed.
Use with adequate ventilation.
Label First Aid:
In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes. Get medical attention if irritation develops or persists. If inhaled, remove to fresh air. Get medical attention for any breathing difficulty.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 2, 3, 11, 15, 16.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)

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